For an oocyte being All set for fertilization and development into an embryo, the correct set of genes must be turned on. Namekawa suspected this pre-programming in the oocyte genome comes about in many stages — the very first one starting off around the time a female is born. He thought that chromatin remodeling proteins did much of the perform, by shifting spools all around.
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This protein may perhaps “set up and preserve the chromatin point out,” states Namekawa — keeping the spools in position and also the oocytes genetically primed as the mouse matures.
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